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How to prepare for a blood pressure test Not getting enough physical activity. Smoking or using illegal drugs such as cocaine, “bath salts,” and methamphetamine. Not getting enough good-quality sleep. Medicines Some prescription and over-the-counter medicines can make it more difficult for your body to control your blood pressure. Medicines that can raise your blood pressure include antidepressants, decongestants (medicines to relieve a stuffy nose), hormonal birth control pills, and non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen. Other medical conditions Other medical conditions change the way your body controls fluids, sodium, and hormone in your blood.